Protein Modification Reagents
Medchemexpress LLC Amino-PEG1-C2-acid | 144942-89-2 | 98.0% | 133.15 | 100 MG
Amino-PEG1-C2-acid is a PEG-based PROTAC linker utilized in the synthesis of PROTACs. This product is for research use only. PROTACs function by containing two distinct ligands connected by a linker, one binding to an E3 ubiquitin ligase and the other to the target protein. They harness the intracellular ubiquitin-proteasome system to facilitate the selective degradation of target proteins.
- Used in the synthesis of PROTACs
- Exploits the intracellular ubiquitin-proteasome system
- Enables selective degradation of target proteins
- Suitable for research use only
Medchemexpress LLC Azido-PEG20-alcohol | 1637297-21-2 | >98% | C40H81N3O20 | 100 MG
Azido-PEG20-alcohol is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. It is also a click chemistry reagent containing an Azide group, enabling copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with Alkyne groups, and strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with DBCO or BCN groups.
- PEG-based PROTAC linker
- Used in the synthesis of PROTACs
- Click chemistry reagent
- Contains an azide group
- Enables copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with alkyne groups
- Undergoes strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with DBCO or BCN groups
Medchemexpress LLC 3,6,9,12,15-Pentaoxaoctadec-17-ynoic acid | 1429934-37-1 | ≥97.0% | 290.31 | 25 MG
Propargyl-PEG4-CH2COOH is a PEG-based PROTAC linker and a click chemistry reagent. It contains an Alkyne group that can engage in copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions with Azide group-containing molecules. This linker is crucial for synthesizing PROTACs, which utilize the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
- PEG-based PROTAC linker
- Used in the synthesis of PROTACs
- Functions as a click chemistry reagent
- Contains an alkyne group for CuAAc reactions
- Enables targeted protein degradation
Medchemexpress LLC TCO-PEG-TCO | 97.1% | 25 MG
TCO-PEG-TCO is a PEG-based PROTAC linker utilized in the synthesis of PROTACs. It functions as a click chemistry reagent, incorporating a TCO group that can engage in an inverse electron demand Diels-Alder reaction (iEDDA) with molecules possessing Tetrazine groups. PROTACs, composed of two distinct ligands connected by a linker, target an E3 ubiquitin ligase and a specific protein, leveraging the intracellular ubiquitin-proteasome system for selective degradation of target proteins.
- PEG-based PROTAC linker
- Utilized in PROTAC synthesis
- Functions as a click chemistry reagent
- Incorporates a TCO group
- Engages in inverse electron demand Diels-Alder reaction (iEDDA)
- Leverages the intracellular ubiquitin-proteasome system
- For selective degradation of target proteins
Medchemexpress LLC Biotin-PEG4-amine | 663171-32-2 | 98.0% | C20H38N4O6S | 250 MG
Biotin-PEG4-amine is a biotin-labeled, PEG-based PROTAC linker. It is used in the synthesis of PROTACs, which are compounds designed to exploit the intracellular ubiquitin-proteasome system for the selective degradation of target proteins. PROTACs consist of two different ligands connected by a linker: one binds to an E3 ubiquitin ligase, and the other to a target protein.
- Biotin-labeled compound
- PEG-based linker for PROTAC synthesis
- Utilized in targeted protein degradation
- Leverages the ubiquitin-proteasome system
- Designed with two ligands for E3 ubiquitin ligase and target protein binding
Medchemexpress LLC Mal-PEG-mal (MW 2000) | 98.40% | 250 MG
Mal-PEG-mal (MW 2000) is a PEG-based PROTAC linker utilized in the synthesis of PROTACs. These PROTAC molecules incorporate two distinct ligands connected by a linker: one targets an E3 ubiquitin ligase, while the other targets the desired protein. This mechanism enables PROTACs to leverage the intracellular ubiquitin-proteasome system for the selective degradation of target proteins.
- PEG-based PROTAC linker
- Used in the synthesis of PROTACs
- Exploits the intracellular ubiquitin-proteasome system
- Selectively degrades target proteins
- Purity of 98.40%
- Solid appearance
Medchemexpress LLC Bromoacetamido-PEG5-DOTA | 2353410-19-0 | 98.02% | C30H55BrN6O13 | 25 MG
Bromoacetamido-PEG5-DOTA is a PEG-based PROTAC linker crucial for synthesizing PROTACs. These molecules employ the intracellular ubiquitin-proteasome system to selectively degrade target proteins by linking an E3 ubiquitin ligase ligand with a target protein ligand. It appears as a white to off-white oil and is exclusively for research purposes.
- PEG-based PROTAC linker
- Used in PROTAC synthesis
- Appears as an oil
- Color ranges from white to off-white
- Exclusively for research use
Medchemexpress LLC TCO-PEG4-NHS ester | 1621096-79-4 | 99.2% | C24H38N2O10 | 25 MG
TCO-PEG4-NHS ester is a PEG-based PROTAC linker used in the synthesis of PROTACs. This compound functions as a click chemistry reagent, featuring a TCO group that facilitates an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing Tetrazine groups. PROTACs are composed of two distinct ligands connected by a linker: one ligand targets an E3 ubiquitin ligase, and the other targets a specific protein. PROTACs utilize the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
- PEG-based PROTAC linker
- Used in the synthesis of PROTACs
- Click chemistry reagent
- TCO group facilitates inverse electron demand Diels-Alder reaction (iEDDA) with Tetrazine groups
- Utilizes intracellular ubiquitin-proteasome system to selectively degrade target proteins
- For research use only
Medchemexpress LLC m-PEG4-Hydrazide | 1449390-68-4 | >98% | C10H22N2O5 | 25 MG
m-PEG4-Hydrazide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
- PROTAC linker
- PEG-based
Medchemexpress LLC Dspe-peg-oh (mw 2000) | 892144-24-0 | 99.9% | (C2H4O)nC42H82NO10P | 25 MG
DSPE-PEG-OH (MW 2000) is a hydroxyl-terminated PEGylated phospholipid. Its hydrophobic tail allows for the encapsulation and aggregation of other hydrophobic drugs, and the hydroxyl terminus is suitable for further reactions. This product can be used to prepare liposomes or lipid nanoparticles.
- Hydroxyl-terminated PEGylated phospholipid
- Hydrophobic tail allows encapsulation and aggregation of other hydrophobic drugs
- Hydroxyl terminus is suitable for further reactions
- Can be used to prepare liposomes or lipid nanoparticles
Medchemexpress LLC APN-C3-PEG4-azide | 2183440-32-4 | 98.0% | C24H32N6O6 | 25 MG
APN-C3-PEG4-azide is a PEG-based PROTAC linker utilized in the synthesis of PROTACs. This click chemistry reagent contains an Azide group, enabling it to participate in copper-catalyzed azide-alkyne cycloaddition (CuAAC) reactions with Alkyne groups or strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with DBCO or BCN groups.
- PEG-based PROTAC linker
- Utilized in PROTAC synthesis
- Click chemistry reagent
- Contains an azide group
- Enables copper-catalyzed azide-alkyne cycloaddition (CuAAC)
- Supports strain-promoted alkyne-azide cycloaddition (SPAAC)
- Relevant to cancer targeted therapy and PROTAC research
Medchemexpress LLC Azide-PEG2-Ms | 176520-23-3 | ≥97.0% | C5H11N3O4S | 250 MG
Azide-PEG2-Ms is a PEG-based PROTAC linker utilized in the synthesis of PROTACs. It functions as a click chemistry reagent, containing an Azide group that facilitates copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules possessing Alkyne groups. Additionally, it can engage in strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
- PEG-based PROTAC linker.
- Can be used in the synthesis of PROTACs.
- Click chemistry reagent.
- Contains an azide group.
- Undergoes copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with alkyne groups.
- Undergoes strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with DBCO or BCN groups.
Medchemexpress LLC m-PEG4-CH2-methyl ester | 1920109-55-2 | MFCD26318564 | >98% | C12H24O6 | 25 MG
m-PEG4-CH2-methyl ester is a PROTAC linker that is based on PEG and Alkyl/ester. It can be utilized in the synthesis of PROTACs. PROTACs are designed with two distinct ligands connected by a linker: one ligand targets an E3 ubiquitin ligase, and the other targets the protein of interest. These molecules function by harnessing the intracellular ubiquitin-proteasome system to facilitate the selective degradation of target proteins.
- PEG- and Alkyl/ester-based PROTAC linker.
- Used in the synthesis of PROTACs.
- PROTACs selectively degrade target proteins by exploiting the ubiquitin-proteasome system.
Medchemexpress LLC Azide-PEG-amine | 95.0% | 25 MG
Azide-PEG-amine (MW 2000) is a PEG-based PROTAC linker, essential for synthesizing PROTACs. It acts as a versatile click chemistry reagent, featuring an azide group. This enables its participation in copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne groups, and strain-promoted alkyne-azide cycloaddition (SPAAC) with DBCO or BCN groups. PROTACs utilize this linker to connect ligands, targeting E3 ubiquitin ligase and a protein of interest for selective degradation. This product is for research use only.
- PEG-based PROTAC linker for PROTAC synthesis
- Functions as a click chemistry reagent with an azide group
- Enables copper-catalyzed azide-alkyne cycloaddition (CuAAc)
- Supports strain-promoted alkyne-azide cycloaddition (SPAAC)
- Leverages ubiquitin-proteasome system for selective protein degradation
- Intended for research use only
Medchemexpress LLC Methyltetrazine-PEG4-maleimide | 1802908-02-6 | 98.6% | C24H30N6O7 | 25 MG
Methyltetrazine-PEG4-maleimide is a PEG-based PROTAC linker used in the synthesis of PROTACs. It is also a click chemistry reagent containing a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.
- PEG-based PROTAC linker
- Used in the synthesis of PROTACs
- Click chemistry reagent
- Contains a Tetrazine group
- Undergoes inverse electron demand Diels-Alder reaction (iEDDA) with TCO groups